Publications
Equal Contribution* Corresponding#
Neuronal maturation in development and disease
***First preprint from the lab*** : Yijia Chen*, Hsuan-Ming Chi*, Aileen Tian*, Alison Miller, Tulsi Patel#. From Wiring to Firing: Collapse of embryonic identities and emergence of functional diversity during motor neuron maturation. bioRxiv 2025.08.12.669897; doi: https://doi.org/10.1101/2025.08.12.669897 Link
Emily R. Lowry & Tulsi Patel. Turning back the clock on age-related neurodegeneration. Nature Neuroscience (2025).Research Briefing Link PDF
Emily R. Lowry*, Tulsi Patel*, Jonathon A. Costa, Elizabeth Chang, Shahroz Tariq, Hranush Melikyan, Ian M. Davis, Siaresh Aziz, Georgia Dermentzaki, Francesco Lotti, Hynek Wichterle. Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons. Nature Neuroscience (2025).https://doi.org/10.1038/s41593-025-02033-x. Link PDF
Patel, T.#, Hammelman, J., Aziz, S., Jang, S., Closser, M., Michaels, T., Blum, J., Gifford, D. K., Wichterle, H#. Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro. Nature Communications. 13, 5427 (2022). Link
Patel, T., Hobert, O. Coordinated control of terminal differentiation and restriction of cellular plasticity. eLife. 6:e24100 (2017). Link
Tools for analyzing genomic data
Hammelman, J., Patel, T., Closser, M., Wichterle, H., Gifford, D. K. Ranking reprogramming factors for cell differentiation. Nature Methods. 19(7):812-822 (2022). Link
Reprogramming cell identity
Closser, M., Guo, Y., Wan, P., Patel, T., Jang, S., Hammelman, J., De Nooij, J., Kopunova, R., Mazzoni, E., Ruan, Y., Gifford, D., Wichterle, H. An expansion of genomic regulatory complexity underlies vertebrate neuronal diversity. Neuron. 110(1):70-85.e6 (2022). Link
Mazzoni, E.O.*, Mahony, S.*, Peljto, M.*, Patel, T., Thornton, S.R., McCuine, S., Reeder, C., Boyer, L.A., Young, R.A., Gifford, D.K., et al. Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals. Nature Neuroscience. 16, 1191-1198 (2013). Link
Specification of neuronal identity
Patel, T.*, Tursun, B.*, Rahe, D.P., and Hobert, O. Removal of Polycomb repressive complex 2 makes C. elegans germ cells susceptible to direct conversion into specific somatic cell types. Cell Reports. 2, 1178-1186 (2012). Link
Tursun, B., Patel, T., Kratsios, P., and Hobert, O. Direct conversion of C. elegans germ cells into specific neuron types. Science. 331, 304-308 (2011). Link